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Mouse CD40 Protein, His Tag产品信息
产品编号 KMP3887
产品名称 Mouse CD40 Protein, His Tag
产品描述 The Mouse CD40 Protein(KMP3887) is produced in HEK293 Cells. A DNA sequence encoding the Mouse CD40 (NP_035741.2) (Met1-Arg193) is expressed with a polyhistidine tag at the C-terminus.
分子名称 CD40
物种 Mouse
宿主 HEK293 Cells
规格 50ug, 100ug, 200ug
纯度 >95% as determined by SDS-PAGE
纯化方式 Affinity purification
内毒素水平 <1.0 EU/ug determined by the LAL method
缓冲体系 PBS, pH7.4
产品背景 CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
保存条件 Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
说明 This product is for research use only.
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