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Human CD40 Protein, hFc Tag产品信息
产品编号 KMP2726
产品名称 Human CD40 Protein, hFc Tag
产品描述 The Human CD40 Protein(KMP2726) is produced in HEK293 Cells. The target gene encoding the human CD40 (NP_001241.1) (Met1-Arg193) is expressed with the Fc region of human IgG1 at the C-terminus.
分子名称 CD40
产品别称 肿瘤坏死因子受体超家族成员 5, Human CD40 Protein, hFc Tag, CD40
物种 Human
宿主 HEK293 Cells
规格 50ug, 100ug, 200ug
纯度 >95% as determined by SDS-PAGE
纯化方式 Affinity purification
内毒素水平 <1.0 EU/ug determined by the LAL method
缓冲体系 PBS, pH7.4
产品背景 CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
保存条件 Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
说明 This product is for research use only.
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