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Human CEACAM1 Protein, His Tag, hFc Tag产品信息
产品编号 KMP2750
产品名称 Human CEACAM1 Protein, His Tag, hFc Tag
产品描述 The Human CEACAM1 Protein(KMP2750) is produced in HEK293 Cells. The target gene encoding the extracellular domain of human CEACAM1 (NP_001020083.1) (Met 1-Gly 428) is fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
分子名称 CEACAM1
产品别称 癌胚抗原相关细胞粘附分子1, Human CEACAM1 Protein, His Tag, hFc Tag, CEACAM1
物种 Human
宿主 HEK293 Cells
规格 50ug, 100ug, 200ug
纯度 >90% as determined by SDS-PAGE
纯化方式 Affinity purification
内毒素水平 <1.0 EU/ug determined by the LAL method
缓冲体系 100mM Glycerolcine, 500mM NaCl, 5% Glycerol, 50mM Arg HCl, 50mM Glu, 0.01% Tween 20, pH5.0
产品背景 The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
保存条件 Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
说明 This product is for research use only.
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