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Recombinant Human MPF/Mesothelin/MSLN Protein, His Tag产品信息
产品编号 KMH1416
产品名称 Recombinant Human MPF/Mesothelin/MSLN Protein, His Tag
产品描述 Recombinant Human MPF/Mesothelin/MSLN Protein, His Tag (KMH1416) contains the human MSLN(Leu37-Arg286) was fused with the C-terminal His Tag and expressed in Mammalian cells.
分子名称 MSLN
产品别称 MPF, SMRP, mesothelin
规格 50ug, 100ug
物种 Human
宿主 Mammalian cells
蛋白家族 Other protein
编录号 Q13421
纯度 ≥90% as determined by SDS-PAGE
内毒素水平 < 1.0 EU per ug of the protein as determined by the LAL method.
缓冲体系 PBS
分子量 27.5 kDa
纯化方式 Affinity Purification
产品背景 Mesothelin (MSLN) was initially cloned from a library of human pancreatic cancer cells. It was also identified by a monoclonal antibody, MAb K1, which recognized a glycoprotein present on the surface of mesothelial cells. Mouse and human mesothelin are 69% identical. Mouse MSLN gene encodes a ~71 kD precursor protein of 625 amino acids. The C-terminal glycosylphosphatidylinositol (GPI) anchor addition signal is removed and replaced with a GPI anchor. The MSLN precursor is cleaved by furin into two products, a ~31 kD mature megakaryocyte potentiating factor and a ~4 kD GPI-anchored membrane-bound mature mesothelin. The 4 kD GPI-anchored mesothelin can be released by treatment with phosphatidylinositol-specific phospholipase C. Soluble mesothelin specifically binds to ovarian carcinoma cell line OVCAR-3, mediated by the cancer antigen 125 (CA125), a mucin-like glycoprotein on the surface of tumor cells.
保存条件 Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
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