EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) VP24 Protein, His Tag
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产品编号
KMP4459
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别名
埃博拉病毒病毒蛋白24, EBOV VP24, 24-kD Vacuolar Protein, EBOV VP24 Protein
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规格
- 50ug
- 100ug
- 200ug
产品介绍
| Alias | 埃博拉病毒病毒蛋白24, EBOV VP24, 24-kD Vacuolar Protein, EBOV VP24 Protein |
| Catalog Number | KMP4459 |
| Product Description | The EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) VP24 Protein(KMP4459) is produced in E. coli. A DNA sequence encoding the Zaire ebolavirus(strain H.sapiens-wt/GIN/2014/Kissidougou-C15) VP24 (AHX24653.1) (Met1-Gly233) was expressed with a polyhistidine tag at the N-terminus. |
| Molecular Name | EBOV VP24 |
| Species | EBOV |
| Host | E. coli |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM Tris, 500mM NaCl, 10% Glycerol, pH8.0 |
| Background | Influenza viral nucleoprotein (NP) plays a critical role in virus replication and host adaptation. Nucleoprotein (NP) is an essential multifunctional protein that encapsidates the viral genome and functions as an adapter between the virus and the host cell machinery. NPs contain two nuclear localization signals (NLSs): a well-studied monopartite NLS1 and a less-characterized NLS2, thought to be bipartite. The nucleocapsid is a complex of the viral nucleoprotein, RNA, and several other viral proteins. The nucleoprotein forms large, RNA-bound, helical filaments and acts as a scaffold for additional viral proteins. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
FAQ
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Q1-VP24蛋白在埃博拉病毒中的功能是什么？
VP24抑制宿主干扰素信号通路，促进免疫逃逸，是抗病毒治疗的潜在靶点。
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Q2-能否用于宿主-病毒互作研究？
可以，结合免疫共沉淀（Co-IP）或荧光素酶报告系统，研究其与宿主蛋白的相互作用。
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Q3-如何验证蛋白的活性？
通过STAT1核转运抑制实验，验证其阻断干扰素信号的能力。
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Q4-是否提供磷酸化修饰的VP24蛋白？
支持，通过体外激酶反应或哺乳细胞表达系统实现特定位点磷酸化。
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Q5-运输条件是什么？
液体需干冰运输，冻干粉可常温运输，复溶后分装保存于-80℃。
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